The eastern portion of Washington state is comprised the rolling hills and prairie farmlands of the Palouse and pristine old-growth Umatilla forest.

Spokane is the urban hub of the eastern-most region of Washington. The art of the Inland Empire. The unofficial capita, Spokane was built up around the Spokane River with a waterfront park built on the site of the 1974 World's Fair that features a scenic view of Spokane Falls, fesstivals and a 100-year-old carrousel. The city also is home to Gonzaga University.

On the eastern edge of this region near the Idaho border, south of Spokane, sits Pullman,home of the state's second-largest college, Washington State University.

The area also is renowned for its unique geological features. The largest documented floods in geologic history deposited giant bolders on otherwise flat lands, carved mounds, gorges and now dry falls to created the Channeled Scablands and further west, the Grand Coulee.